Ultrasound Estimated Bladder Weight During the Treatment of Benign Prostatic Hyperplasia with Tamsulosin

Snjezana Milicevic Urology Clinic, Clinical Center Banjaluka, Bosnia and Herzegovina by its thickness and volume, in patients with BPh, in quantitative estimation of hypertrophy degree. Enlarged prostate causes two types of obstruction: a dynamic and mechanical. Functional obstruction (dynamic factor) stems from contractile smooth muscles of the prostate and the urinary bladder neck, which are innervated from autonomous nervous system. Mechanical obstruction (static factor) occurs with massive prostate gland enlargement and it is caused with the deformation of posterior urethra. Adrenoreceptos have a crucial importance in occurrence of symptoms in the lower part of urinary tract caused by benign prostatic hyperplasia. There are three types of postsynaptic α 1adrenoreceptors α 1A, α 1B and α 1D. in the prostate gland most dominant are α 1A (70%) adrenoreceptors compared to α 1D adrenoreceptors. in detrusor of the urinary bladder most dominant are α 1D adrenoreceptors (66%) compared to α 1A (34%). α 1A adrenoreceptors are most probable cause for obstruction occurrence due to benign prostate hyperplasia, with consequential occurrence of urination symptoms, such as more difficult onset of miction, poor flow with terminal drops, prolonged urination, more difficult urination. α 1D adrenoreceptors are responsible for the instability of the bladder and consequential filling symptoms, such as more frequent urge for urination, nocturia, urgency and urgent incontinence. Medicament therapy of benign prostatic hyperplasia have clearly defined indication area, and initial area, whether it is a case of mono or combined therapy, represent antagonist of alpha adrenergic receptors (6,7,8). Because tamsulosin is urology selective α 1A/1D antagonist, which reduce obstructive and irritation symptoms, or symptoms of urination and symptoms of filling.